Design and Synthesis Ligands Tetradents Substituted with Halogenes in α- Position and Conjugation with Riboflavin (Bioconjugates) Conjugate ligands Type TPA’s with Flavonoids as un Electron Mediator

In this article, we describe the process of binding riboflavin to a simple tetradents ligand substituted in α- position from TPAs types, by reacting bromotetraacetate with TPA one pyridine rings nitrile group and two other halogen atoms. This type ligands showed very important properties for activation transfer oxygen substrate presence iron salt. After were obtained, was reduced an amine where it reacts Boc protect hydrogen then bound through under special reactive conditions, form α-8-TPAs N- Ac4riboflavin ligands. compound can be described as molecular tweezers which flavin moiety acts potential electron mediator.